Validation of EPA Method 1633: Semi-Automated Solid Phase Extraction

Validation of EPA Method 1633 has been a critical focus in advancing reliable tools for PFAS detection and analysis. Until recently, the U.S. Environmental Protection Agency (EPA) had not released a standardized method for analyzing PFAS in environmental matrices such as groundwater, surface water, and soils. This lack of consistency led many laboratories to develop independent methodologies, resulting in variable outcomes. The introduction and finalization of EPA Method 1633 has resolved these discrepancies by establishing a validated and standardized protocol for PFAS analysis across multiple sample types.

Validation of EPA Method 1633 has enabled greater reproducibility and confidence in PFAS testing, particularly when using semi-automated solid phase extraction systems that align with the method’s requirements.

Finalization of EPA Method 1633

In January 2024, the EPA officially finalized Method 1633, setting a major benchmark in environmental testing. The method provides a complete framework for detecting PFAS in a wide range of complex matrices, including:

• ✔ Groundwater, surface water, and wastewater

• ✔ Landfill leachate, soils, and sediments

• ✔ Biosolids and biological tissue

EZPFC® Semi-Automated SPE for Method 1633

To support the adoption of EPA Method 1633, FMS developed the EZPFC® Semi-Automated Solid Phase Extraction (SPE) system, offering a cost-effective and high-throughput approach to PFAS extraction. This system enhances laboratory efficiency by automating key sample preparation steps while ensuring high-quality, contamination-free results.

Key Benefits of EZPFC® for Method 1633

• Reliable & Standardized Workflow – Reduces inconsistencies in sample preparation
• High Sample Throughput – Increases processing efficiency for environmental labs
• Precision & Accuracy – Ensures optimal PFAS recovery with minimal contamination risk
• Cost-Effective Solution – Provides an affordable alternative to fully automated systems

With EPA Method 1633 now finalized, laboratories can confidently apply a validated, high-precision approach to PFAS testing. To explore key challenges in PFAS extraction, visit FMS’s Challenges in PFAS Extraction.

For more details on EPA Method 1633, access the official EPA publication.